Ki-Mcm6, a New Monoclonal Antibody Specific to Mcm6: Comparison of the Distribution Profile of Mcm6 and the Ki-67 Antigen
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چکیده
منابع مشابه
High expression of minichromosome maintenance protein 6 in classic Hodgkin's lymphoma points to a cell cycle arrest in G1 phase.
BACKGROUND Minichromosome maintenance protein 6 (MCM6) is one of the six proteins of minichromosome maintenance family that are involved in the initiation of DNA replication and thus represent a marker for proliferating cells. The aim of this study was to determine the proliferation characteristics of neoplastic cells in patients with classic Hodgkin's lymphoma. METHODS Paraffin-embedded bloc...
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15 صفحه اولMeasurement of Ki-67 antigen in 159 pituitary adenomas using the MIB-1 monoclonal antibody.
Pituitary adenomas sometimes show rapid growth and recurrence, and about one third invade the structures surrounding the sella turcica. In an attempt to determine aggressive behavior at an early stage, we used the MIB-1 antibody to identify the Ki-67 antigen. The present study was designed to evaluate pituitary adenomatous tissue in terms of secretion and proliferation and to correlate the Ki-6...
متن کاملAssessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen.
AIMS To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole. METHODS Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIB1. RESULTS Ki67 immunoreactivity was significantly higher in the tissue f...
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OBJECTIVE To assess the potential usefulness of Ki-67 antigen expression as a predictor of outcome in ovarian cancer through the analysis of MIB-1 monoclonal antibody reactivity. METHODS Cell proliferation and clinicopathologic variables were assessed in 26 patients with primary epithelial ovarian cancer who had undergone exploratory laparotomy. The expression of primary tumor proliferation r...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2001
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3780328